Diagnostic and Therapeutic Multi-gene Assays Employing State-of-the-Art NGS and a Systems Genetics Approach

Lung cancer is the leading cause of cancer death in the U.S. and worldwide. In 2012, it is estimated that in the U.S., 226,160 new cases of lung cancer will be diagnosed and that 160,340 people will die of the disease, an annual mortality exceeding that of breast, prostate, and colorectal cancer combined. Despite decades of research, overall 5-year survival has remained at a poor 15-17%. Because lung cancer develops deep within the chest cavity and typically causes no symptoms until the disease is advanced and incurable, early detection is critical. Investigators in the Kim Lab are deeply committed to reversing the inexorable course of lung cancer through bold investigation and innovative science using the latest next-generation sequencing technology.

Il-Jin Kim, Ph.D., Director of Applied Genomics in the UCSF Thoracic Oncology Laboratory, has extensive experience in early detection, having led an effort to screen 1,000 patients in 400 families for major inherited conditions in the Korean Hereditary Tumor Registry.  Molecular diagnostic screening is the future of early detection. The same molecular biomarkers also have in assessing prognosis and predicting response to treatement. Current genetic assays are technically complex, expensive, and slow making them impractical for routine screening. The Kim Lab is developing rapid, high-throughput, high-quality and cost-effective diagnostic assays for lung cancer to meet this unmet medical need.

Recent Publications

Fang LT, Lee S, Choi H, Kim HK, Jew G, Kang HC, Chen L, Jablons D, Kim IJ
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
International journal of oncology, Oct-25-2013; [Epub ahead of print].
Chung Kang H, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A
Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.
The Journal of investigative dermatology, Jul-01-2013; 1337: 1907-10.  Epub 2013 Mar 07.
Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B
Targeting Gli transcription activation by small molecule suppresses tumor growth.
Oncogene, May-20-2013; [Epub ahead of print].
Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Nature communications, 4: 1701.
Kim JW, Lee S, Lui N, Choi H, Mulvihill M, Fang LT, Kang HC, Kwon YW, Jablons D, Kim IJ
A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease.
Oncology reports, Oct-01-2012; 284: 1225-30.  Epub 2012 Jul 26.
Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
International journal of oncology, Jun-01-2012; 406: 1900-6.  Epub 2012 Mar 07.
Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Molecular cancer research : MCR, Jun-01-2012; 106: 834-44.  Epub 2012 May 23.
Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A
Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma.
Oncogene, Mar-01-2012; 319: 1176-80.  Epub 2011 Jul 25.
Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L
Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.
PloS one, 76: e38996.
Mulvihill MS, Kwon YW, Lee S, Fang LT, Choi H, Ray R, Kang HC, Mao JH, Jablons D, Kim IJ
Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.
PloS one, 78: e42264.
Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A
Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility.
Genome biology, 121: R5.  Epub 2011 Jan 18.
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